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產(chǎn)品名稱： Research Grade Adalimumab ( 阿達(dá)木單抗 )
產(chǎn)品貨號： CSD00093
貨期： 現(xiàn)貨
價(jià)格與訂購： 2480
數(shù)量：

庫存： 100
規(guī)格： 100μg

產(chǎn)品信息
如何訂購

貨號（Catalog No.）

CSD00093

通用名INN

Adalimumab

純度(Purity)

>95%

濃度( Concentration)

1mg/ml

Formulation

PBS buffer PH7.5

Source

CHO cells

內(nèi)毒素(Endotoxin level)

Please contact with the lab for this information.

產(chǎn)品描述(Description)

Adalimumab is a subcutaneously administered biological disease modifier for the treatment of rheumatoid arthritis and other chronic debilitating diseases mediated by tumor necrosis factor 2, 3. It was originally launched by Abbvie in the U.S. and approved in 2002 by the FDA 1. This drug is frequently known as Humira. It is produced by recombinant DNA technology using a mammalian cell expression system. This drug is available in a prefilled syringe form and convenient pen form for subcutaneous self-administered doses 1. A new biosimilar to adalimumab, named adalimumab-adaz, was approved by the FDA on October 31, 2018. This biosimilar is known as Hyrimoz, and is a trademark of Novartis AG 9.

別名(Alternative names)

D2E7

靶點(diǎn);物種(Specificity target name;species)

TNFSF2/TNF-alpha/TNFA[Homo sapiens]

活性研究（體外/體內(nèi)研究）(Activity in vitro)

Adalimumab (anti-TNF-alpha) blocks the interaction of TNF with the p55 and p75 cell surface TNF receptors, thereby neutralising the activity of this cytokine. Through its anti-TNF actions, adalimumab reduces concentrations of matrix metalloproteases (MMP-1 and -3) and other markers of cartilage and synovium turnover, reduces of matrix metalloproteases (MMP-1 and -3) and other markers of cartilage and synovium turnover, and reduces concentrations of acute phase reactants of inflammation (C-reactive protein [CRP] and erythrocyte sedimentation rate [ESR]) and serum cytokines (IL-1β mRNA, IL-1 receptor antagonist, IL-6).

種類(Species)

Homo sapiens

受體鑒定(Receptor identification)

IgG1-kappa

分子量(MV)

148000.00 Da

CAS

331731-18-1

存儲條件(Storage)

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

Store at +4°C short term (1-2 weeks).

Store at -20 °C 12 months.